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3 minutes ago, Vanilla Strange Gato said:

Damn.  Hope the recovery from that is quick!

 

Also hope you were heavily sedated for that procedure. 

I had weak ass nitrous oxide and nothing else.  Drove home from north Austin feeling like I had to piss and shit at the same time, just like normal traffic.

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  • Well, other than my wife, and my doctor, you fuckers are the only ones to know.  I had an endoscopy last Thursday as I have had increasing difficulty swallowing food.  The scope showed a stricture (na

  • So some positive news, relatively.  Had both an endoscopic ultrasound and PET CT this past week.  Ultrasound showed a sizable tumor.  But PET CT showed very little spread.  And that’s the key.  Now th

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11 minutes ago, Vanilla Strange Gato said:

Nope. I am gonna need to be out for that 

Hope you never need to deal with it.  Not pleasant but hopefully the results say I can do nothing for another couple of years.  My Gleason score and Decipher tests say low risk.  

Had my second prostate biopsy today.  Good times.  Nothing like having a Louisville slugger with a hole punch on it stuck up your ass.  10 to 14 days until I get the results.  Hopefully the tumor is still dormant.  

But to be clear, you moaning with pleasure throughout the procedure DID give the doc some mixed signals.
34 minutes ago, Brisketexan said:


But to be clear, you moaning with pleasure throughout the procedure DID give the doc some mixed signals.

If moaning = flinching and clinching then yeah.

4 hours ago, Dbeasy said:

So mine have been like someone stables my testicles to the wall and beat my prostate with a baseball bat.

 

 

4 hours ago, Judge Roybeanbag said:

As a side note I give any gay guys credit.  Having this stuck up your butt is a teeth clinching exercise.  image.jpeg.3e2d79136590b6f3fff6f68427551fdd.jpeg

Good thing they put a rubber on that plastic prong, else youda been drippin with robot jizz on your Walk of Shame you lil hoochie.

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Well FUCK CANCER #154,785.  My brother called me to let me know he's been diagnosed with anal cancer.  Spread to a couple of lymph nodes, but no organs.  Starting chemo and radiation Dec 1.  Chemo combo is Mitomycin and Xeloda if anyone has had that combo.  He's flying down this weekend to just get away from it for a couple of days.  Gonna take him out on the water Saturday.  A little ocean breeze can go a long way in setting one's mind right.  But fuck, man.

4 hours ago, Sbbruin said:

Well FUCK CANCER #154,785.  My brother called me to let me know he's been diagnosed with anal cancer.  Spread to a couple of lymph nodes, but no organs.  Starting chemo and radiation Dec 1.  Chemo combo is Mitomycin and Xeloda if anyone has had that combo.  He's flying down this weekend to just get away from it for a couple of days.  Gonna take him out on the water Saturday.  A little ocean breeze can go a long way in setting one's mind right.  But fuck, man.

Well dammit. put him in some tight swim suit because we don't need the fish all getting anal cancer too.

Seriously, nuke it from orbit.

12 minutes ago, RDCanecutter said:

Well dammit. put him in some tight swim suit because we don't need the fish all getting anal cancer too.

Seriously, nuke it from orbit.

An ass-plosion of chemo, if you will.

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We did my one year bone marrow tests on Halloween and finally got the final results yesterday.  I am officially in remission at the 1 year mark.  These tests last year showed returning disease and sent us to transplant #2.  Basically, I have not been cancer free for this long in over 3 years.  By no means am I going to start spiking footballs, but it is a huge relief to get over this milestone.  Next tests are 6 months away.

For now, I am just getting my head around everything.  We have had optimism in the past and keep getting kicked down, so we are keeping celebration at a minimum.  I need to stay diligent about working out and eating healthier with minimal booze.  It sucks, but need to keep the peddle down.

As my wife and I have always said, we are just buying time.  The longer we go, the longer they will have to find better treatments.  I said last Christmas that I just wanted to see my youngest get to kindergarten.  Now, we're looking at 1st grade.  A bit at a time.

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On 11/6/2025 at 12:25 AM, Bevo said:

 

Do you happen to know which kinase (or other protein) the mutated gene codes for? 

It's an nrg1 protein fusion. 

 

Well, after increasing problems the last few weeks, I got the call yesterday that the extensive liver tumors have started to majorly block liver function and failure is on the way. Unless some miracle happens and they start to shrink my timeline is a few weeks to a few months. 

4 hours ago, seven said:

It's an nrg1 protein fusion. 

 

Well, after increasing problems the last few weeks, I got the call yesterday that the extensive liver tumors have started to majorly block liver function and failure is on the way. Unless some miracle happens and they start to shrink my timeline is a few weeks to a few months. 

 

That sucks. I'm very sorry to hear that news. Stay strong.

I assume they already tried zenocutuzumab (Bizengri). I can't remember offhand what else is in development, but I'll check it out. 

Seribantumab doesn't look great in clinical trials

Patritumab deruxtecan is further along but I have my doubts 

Hummingbird Biosciences has some interesting stuff but it is too early stage and for the most part being done outside the US anyway. I think the company is in Singapore. 

 

6 hours ago, Bevo said:

 

That sucks. I'm very sorry to hear that news. Stay strong.

I assume they already tried zenocutuzumab (Bizengri). I can't remember offhand what else is in development, but I'll check it out. 

Couldn't get accepted to the trial, then I think it was released recently but Medicare wouldn't approve "off-label" since it's primary is lung cancer. I took the oral version and it did nothing. I might be getting mixed up with something else though. 

Edited by seven

41 minutes ago, seven said:

Couldn't get accepted to the trial, then I think it was released recently but Medicare wouldn't approve "off-label" since it's primary is lung cancer. I took the oral version and it did nothing. I might be getting mixed up with something else though. 


 

No, that makes sense. No oral version though.

Edited by Bevo

12 hours ago, seven said:

It's an nrg1 protein fusion. 

 

Well, after increasing problems the last few weeks, I got the call yesterday that the extensive liver tumors have started to majorly block liver function and failure is on the way. Unless some miracle happens and they start to shrink my timeline is a few weeks to a few months. 

So sorry seven.  Just keep fighting the fight.  Until you just want comfort.  Then focus on that.  Buncha assholes keeping you tight in our thoughts.

13 hours ago, Stringer said:

We did my one year bone marrow tests on Halloween and finally got the final results yesterday.  I am officially in remission at the 1 year mark.  These tests last year showed returning disease and sent us to transplant #2.  Basically, I have not been cancer free for this long in over 3 years.  By no means am I going to start spiking footballs, but it is a huge relief to get over this milestone.  Next tests are 6 months away.

For now, I am just getting my head around everything.  We have had optimism in the past and keep getting kicked down, so we are keeping celebration at a minimum.  I need to stay diligent about working out and eating healthier with minimal booze.  It sucks, but need to keep the peddle down.

As my wife and I have always said, we are just buying time.  The longer we go, the longer they will have to find better treatments.  I said last Christmas that I just wanted to see my youngest get to kindergarten.  Now, we're looking at 1st grade.  A bit at a time.

Enjoy the free baseball! Take every inning you can get.

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13 hours ago, seven said:

It's an nrg1 protein fusion. 

 

Well, after increasing problems the last few weeks, I got the call yesterday that the extensive liver tumors have started to majorly block liver function and failure is on the way. Unless some miracle happens and they start to shrink my timeline is a few weeks to a few months. 

That's that cold reality pushing in.

Maybe they shrink anyway. Maybe you wake up and you're fishing with your Granddad.

I wish you well.

On 11/19/2025 at 11:15 PM, seven said:

It's an nrg1 protein fusion. 

 

Well, after increasing problems the last few weeks, I got the call yesterday that the extensive liver tumors have started to majorly block liver function and failure is on the way. Unless some miracle happens and they start to shrink my timeline is a few weeks to a few months. 

 

On 11/20/2025 at 9:49 AM, seven said:

Couldn't get accepted to the trial, then I think it was released recently but Medicare wouldn't approve "off-label" since it's primary is lung cancer. I took the oral version and it did nothing. I might be getting mixed up with something else though. 

so sorry to hear this, seven. f cancer. you've always been a big part of this community and that will remain the case regardless of how this goes from here. keep your head up and do not go gently into that good night, my friend. try to get everything you can out of life from here.

On 11/21/2025 at 3:29 PM, sidis said:

 

so sorry to hear this, seven. f cancer. you've always been a big part of this community and that will remain the case regardless of how this goes from here. keep your head up and do not go gently into that good night, my friend. try to get everything you can out of life from here.

This, but it is pretty damn clear that seven is already dialed in to that.

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About a month ago, my wife found out she has breast cancer. We freaked out, of course. But after meeting with doctors, it turned out that she had the best case senario. It was confined to a milk duct and it was detected at the earliest possible time. My wife's family history with cancer is horrible, so she's been doing mammograms and MRIs on a strict schedule, and it was caught. It is what they call "Stage Zero". No chemo or radiation. 

However, if she chose to just do a lumpectomy, her chances of getting it again in the next 10 years would be 30%, because of her genetic make up. She had genetic testing done years ago. A double mastectomy put her at 1-3%. She opted for the double, I can't blame her. The surgery was monday and it was a great success. She goes back in a couple of weeks for the reconstruction. And yes, she's getting the upgrayyyyed. 

I've been keeping it together, for the most part. When it comes to big emotions, I'm a bottler. I'm sure it will get out one day, maybe soon. She always tries to get me to "let it out" but I fight it. Just instinct, I guess. I didn't have a bad childhood, where I wasn't allowed to be emotional. I don't know why I'm this way.

She's already back to her old self, other than soreness. It's great to see. 

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Cleared for surgery by all the Drs.

It will be soft tissue removal which will lead to reconstructiv surgery.

A third of my tricep will be removed, so they will graft from my ulnar nerve which I thought i was losing.

I have no fucking clue. I just know this shit aint killng me yet and I keep my arm.

MDA puts everyone through the ringer. Their methodology reminds me of Mindhunter. 

If something is to be found,they will find it.

They are the FBI of cancer.

Edited by MissingInAction

That’s great news MIA!  I hope that your tricep continues to serve you like it means it. Hook ‘em!

5 hours ago, Sandman said:

About a month ago, my wife found out she has breast cancer. We freaked out, of course. But after meeting with doctors, it turned out that she had the best case senario. It was confined to a milk duct and it was detected at the earliest possible time. My wife's family history with cancer is horrible, so she's been doing mammograms and MRIs on a strict schedule, and it was caught. It is what they call "Stage Zero". No chemo or radiation. 

However, if she chose to just do a lumpectomy, her chances of getting it again in the next 10 years would be 30%, because of her genetic make up. She had genetic testing done years ago. A double mastectomy put her at 1-3%. She opted for the double, I can't blame her. The surgery was monday and it was a great success. She goes back in a couple of weeks for the reconstruction. And yes, she's getting the upgrayyyyed. 

I've been keeping it together, for the most part. When it comes to big emotions, I'm a bottler. I'm sure it will get out one day, maybe soon. She always tries to get me to "let it out" but I fight it. Just instinct, I guess. I didn't have a bad childhood, where I wasn't allowed to be emotional. I don't know why I'm this way.

She's already back to her old self, other than soreness. It's great to see. 

Did she also do testing on the cancer cells themselves to verify they aren’t the type that requires chemo and radiation? That is a second critical gene test. I’m sure she did, but I have found some doctors don’t do that test when the cancer is caught early, and they really should. 

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12 hours ago, Gatorubet said:

This, but it is pretty damn clear that seven is already dialed in to that.

I feel extremely lucky actually. This week is my 3 year anniversary of being diagnosed. After that I tried to work part-time for a few months but my lack of fucks was too much to overcome and I decided I was never going to work again. I went through about 18 months of infusion hell and what it bought me was 18 months of the happiest time of my life. I have visited around 20 countries, traveling for months at a time.  This is only possible because I drained my retirement accounts and had next to no responsibilities. When I was home I did nothing but smoke weed and play video games. I am a person who has struggled with self acceptance and self hatred my entire life and I completely gave all of that up, it just didn't matter to me anymore and I lived the life I wanted to live. I was extremely unhappy in my worker bee life and getting cancer opened my eyes to just how unhappy I was.

Anyway, it's kind of shocking how quickly I'm deteriorating now. 6 weeks ago I was walking around Spain for hours with no significant issues. Earlier this week I felt as though I had ran a marathon for a walk from the parking lot up to the hospital lab, a journey I've easily made well over 100 times the last 3 years, even during the toughest of the chemo days. I'll be moving in with my mom and her husband next week and then I'll probably make the choice to begin hospice pretty soon after that. 

I thank everyone for the support and this thread is really the only place I talk about this stuff so it's definitely been positive impact on my experience. 

Thank you, seven.

Your experience puts everything into perspective. 

Life.

I am in pre staging now so who knows what the fuck comes next.

Already not giving a fuck about work, and it's difficult to be an asset now. Everything you said here hits close. Thank you.

17 minutes ago, seven said:

I feel extremely lucky actually. This week is my 3 year anniversary of being diagnosed. After that I tried to work part-time for a few months but my lack of fucks was too much to overcome and I decided I was never going to work again. I went through about 18 months of infusion hell and what it bought me was 18 months of the happiest time of my life. I have visited around 20 countries, traveling for months at a time.  This is only possible because I drained my retirement accounts and had next to no responsibilities. When I was home I did nothing but smoke weed and play video games. I am a person who has struggled with self acceptance and self hatred my entire life and I completely gave all of that up, it just didn't matter to me anymore and I lived the life I wanted to live. I was extremely unhappy in my worker bee life and getting cancer opened my eyes to just how unhappy I was.

Anyway, it's kind of shocking how quickly I'm deteriorating now. 6 weeks ago I was walking around Spain for hours with no significant issues. Earlier this week I felt as though I had ran a marathon for a walk from the parking lot up to the hospital lab, a journey I've easily made well over 100 times the last 3 years, even during the toughest of the chemo days. I'll be moving in with my mom and her husband next week and then I'll probably make the choice to begin hospice pretty soon after that. 

I thank everyone for the support and this thread is really the only place I talk about this stuff so it's definitely been positive impact on my experience. 

While we can’t put ourselves in your position, many of us went through the fight and can sympathize with your journey.  Sounds like you were able to live life to the fullest recently.  That’s wonderful.  Wishing you peace brother.

17 hours ago, MissingInAction said:

A third of my tricep will be removed

Just so long as you've got enough to keep that forearm moving...

18 hours ago, MissingInAction said:

A third of my tricep will be removed, so they will graft from my ulnar nerve which I thought i was losing.

Third of your tricep? That leaves you with a sexy duocep!  

Now we just need to fill out the Bengal tiger injury details.  <“ I was on the second tallest elephant - immediately to the left of the Maharaja.  The beaters advanced, when out of the corner of my eye I caught an orange blur…”>

Inner peace and acceptance is a wonderful gift seven, no matter the journey.   And as mankind has understood over vast millennia, the start of an amazing journey.

20 hours ago, Gatorubet said:

Third of your tricep? That leaves you with a sexy duocep!  

Now we just need to fill out the Bengal tiger injury details.  <“ I was on the second tallest elephant - immediately to the left of the Maharaja.  The beaters advanced, when out of the corner of my eye I caught an orange blur…”>

I'll ask the surgeon for some sweet tiger claw scars.

3 hours ago, MissingInAction said:

I'll ask the surgeon for some sweet tiger claw scars.

Had an uncle who had an accidental shotgun discharged into his bicep.  They did a pretty good job saving his arm and the bicep but the scars were bad.  This was in the mid-70’s. 
 

He got asked about it a lot.  Eventually he went with either “I got hit when I was in ‘Nam” or “got bit by a shark when I was surfing”. 
 

You should go with “took a couple rounds from a cartel thug back when I was a DEA agent.  He didn’t fair as well.”

  • Popular Post

Just signed off to donate my lump to research. Apparently this cancer is so rare its got the nerds in a tizzy.

May explain why MDA has covered all of the treatment cost.

Just signed off to donate my lump to research. Apparently this cancer is so rare its got the nerds in a tizzy.
May explain why MDA has covered all of the treatment cost.

They’re gonna find out that it’s so rare because it is only acquired by insanely high rates of drug use and compulsive masturbation.
2 minutes ago, Brisketexan said:


They’re gonna find out that it’s so rare because it is only acquired by insanely high rates of drug use and compulsive masturbation.

To be clear, Brisket is not casting shade on the normal rates of drug use and compulsive masturbation. Carry on. 

To be clear, Brisket is not casting shade on the normal rates of drug use and compulsive masturbation. Carry on. 

Obviously.
35 minutes ago, Brisketexan said:

insanely high rates of drug use and compulsive masturbation.

I wasn't aware that there could be too much or too often.

1 hour ago, MissingInAction said:

Just signed off to donate my lump to research. Apparently this cancer is so rare its got the nerds in a tizzy.

May explain why MDA has covered all of the treatment cost.

 

i should get a side note for filling you full of msg !!!

On 11/26/2025 at 11:26 PM, seven said:

I feel extremely lucky actually. This week is my 3 year anniversary of being diagnosed. After that I tried to work part-time for a few months but my lack of fucks was too much to overcome and I decided I was never going to work again. I went through about 18 months of infusion hell and what it bought me was 18 months of the happiest time of my life. I have visited around 20 countries, traveling for months at a time.  This is only possible because I drained my retirement accounts and had next to no responsibilities. When I was home I did nothing but smoke weed and play video games. I am a person who has struggled with self acceptance and self hatred my entire life and I completely gave all of that up, it just didn't matter to me anymore and I lived the life I wanted to live. I was extremely unhappy in my worker bee life and getting cancer opened my eyes to just how unhappy I was.

Anyway, it's kind of shocking how quickly I'm deteriorating now. 6 weeks ago I was walking around Spain for hours with no significant issues. Earlier this week I felt as though I had ran a marathon for a walk from the parking lot up to the hospital lab, a journey I've easily made well over 100 times the last 3 years, even during the toughest of the chemo days. I'll be moving in with my mom and her husband next week and then I'll probably make the choice to begin hospice pretty soon after that. 

I thank everyone for the support and this thread is really the only place I talk about this stuff so it's definitely been positive impact on my experience. 

 

i hope you and the fam have a great holiday

god bless 

1 hour ago, Brisketexan said:


They’re gonna find out that it’s so rare because it is only acquired by insanely high rates of drug use and compulsive masturbation.

221,222.. whatever works.

When I came out of the last procedure the anesthesiologist said he had never seen anything like it. They couldnt keep me under no matter how much shit they pumped into me.

May be from the SERE training many moons ago.

Edited by MissingInAction

1 hour ago, MissingInAction said:

221,222.. whatever works.

When I came out of the last procedure the anesthesiologist said he had never seen anything like it. They couldnt keep me under no matter how much shit they pumped into me.

Sounds like the second scene of a vampire movie.

48 minutes ago, RDCanecutter said:

Sounds like the second scene of a vampire movie.

IMG_5555.gif.28aa325165039679273d5d7d7f2d2abc.gif

How did that go, exactly? Twilight sedation?

11 minutes ago, Basil said:

How did that go, exactly? Twilight sedation?

Is that when you can’t even act dead and you wake up all sparkly looking?

2 minutes ago, Gatorubet said:

Is that when you can’t even act dead and you wake up all sparkly looking?

That'd be Tuesday.

19 hours ago, MissingInAction said:

221,222.. whatever works.

When I came out of the last procedure the anesthesiologist said he had never seen anything like it. They couldnt keep me under no matter how much shit they pumped into me.

May be from the SERE training many moons ago.

Redhead.

We learned this this summer, as we had our second kid, who has reddish hair, and had to have heart surgery, and the director for anesthesia at Dell Children’s was the Doc keeping him under said the same thing, and that it was very common for redheads to have a crazy high tolerance for knock out meds.  

21 minutes ago, UnivTex34 said:

Redhead.

We learned this this summer, as we had our second kid, who has reddish hair, and had to have heart surgery, and the director for anesthesia at Dell Children’s was the Doc keeping him under said the same thing, and that it was very common for redheads to have a crazy high tolerance for knock out meds.  

Don't I know it.  That's why I only kidnap blonde and brunette chicks for my sex dungeon.

Wait, we're in open forum here....shit....too late to edit.

Just kidding!

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